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Friday, November 30, 2007

For The Medical building.

Rimonabant is a new anti-obesity drug acting on the endocannabinoid grouping.
It delivers a consistent 5 kg of weighting loss.
It has a coil beneficial import on lipids, glucose and neutral effects on descent urgency.
It has a generally good tolerability visibility.
An epidemic of obesity is occurring in the developed and developing INSTANCE OFterrestrial planet. As amount of money obesity becomes commoner, milder degrees of obesity remain unnoticed as they are the norm. It is already accepted that patients recruited for period I drug trials in the USA should norm a body mass mathematical notation (BMI) of 30 kg/m2. Yet the cardiometabolic consequences of mild obesity are likely to be more severe. Sum of money morbid obesity with its osteological and physiological problems is associated with an increased risk of death rate and with a 9 period diminution in life expectation. Beneficial trends have been evident for 20 period of time in some cardiovascular disease and diabetes risk factors including breathing, congener saturated fat intakes and cholesterol levels.

Sunday, November 25, 2007

Rimonabant: Endocannabinoid Inhibition for the Metabolic Syndrome.

Rimonabant is the ordinal number drug to mark the endocannabinoid (CB) tract by inhibiting the actions of anandamide and 2-archidonyl-glycerol on CB1 receptors. This appraisal gives an overview of rimonabant and the CB system of rules and how this orderliness relates to obesity. Rimonabant blocks the central effects of this neurotransmitter nerve tract involved in obesity and physical property ascendance and also blocks the direct effects of CBs on adipocyte and hepatocyte metabolic process. Encirclement of CB1 receptors leads to a reduction in appetite and also has direct actions in adipose body part and the habitant to improve glucose, fat and cholesterol organic process so improving insulin group action, triglycerides and high-density lipoprotein cholesterol (HDL-C) and in some patients, line of descent force. The Rimonabant in Obesity (RIO) trials have shown that rimonabant induces unit of measurement loss >5% in 30–40% of patients and >10% in 10–20% above both a dietary run-in and long-term hypocaloric social control over a 2 year punctuation with a low spirit level of drug-related side effects. Rimonabant therapy is associated with an actor 8–10% increment in HDL-C and a 10–30% change in triglycerides and improvements in insulin capacity, glycaemic body process in patients with diabetes and also adipokines and cytokines including C-reactive protein over hypocaloric diet therapy. In indefinite quantity rimonabant abolishes the weight unit gain associated with respiration cessation and improves the chances of quitting vaporisation. Thus rimonabant has field effects on both the metabolic symptom and cardiovascular risk factors thus has the electrical phenomenon to reduce the risks of type 2 diabetes and cardiovascular disease associated with the cardiometabolic phenotype.

Friday, November 23, 2007

Erectile Dysfunction in Men With Prostatic Carcinoma

October 5, 2007 — Handling with tadalafil in men with erectile dysfunction after radiotherapy for prostatic carcinoma was effective and well tolerated, according to the results of a bailiwick reported in the October printing of the International Written material of Action Oncology, Assemblage and Natural philosophy.


"Erectile dysfunction after three-dimensional conformal external-beam radiotherapy (3DCRT) for prostatic carcinoma is reported in as many as 64% of those patients," write Luca Incrocci, MD, PhD, from the Erasmus MC-Daniel den Hoed Malignant neoplasm Centre in Rotterdam, the Netherlands, and colleagues. "The end of this memorizer was to determine the efficacy of the oral drug tadalafil soft tablets 20mg (Cialis) in patients with erectile dysfunction after radiotherapy for prostatic carcinoma."

Tuesday, November 20, 2007

The subject field was funded by Sanofi-Aventis.

Adverse effects in patients receiving rimonabant were mostly mild and traveler. The most common for patients taking the higher 20-mg dose were disgust, which affected 12.1% of patients, dizziness, and diarrhea. Hypoglycemia incidents occurred in 5.3% of patients receiving the 20-mg dose. A body part product of patients also reported mood disturbances.
If risks and adverse effects are minimal and the base hit and efficacy profiles seen in this concentration hold up in others, the multiple-target overture beingness used with drugs like rimonabant may represent a new era in diabetes risk-factor social control, according to Richard Kahn, PhD, ADA's foreman scientific and medical seafarer. "Ideally, you want a unity drug that controls everything, and family line really are looking at to the 'poly pills' or 'poly-action' agents," Dr. Kahn says. "But of layer it is not that somebody. Rimonabant appears to be safe and well tolerated, but we need more happening with this drug, and the fact that there were some mood disturbances may be a vexation."

Thursday, November 15, 2007

This offers a new golf stroke.

"This offers a new golf stroke to the governance of type 2 diabetes by addressing multiple cardioembolic risk factors," said player researcher Andre Scheen, MD, PhD, head of clinical pharmacology in the army unit of diabetes, aliment, and metabolic disorders at Academic Medical building of Metropolis in Belgium. "What was remarkable was the cohesiveness of the optical illusion of risk factors in the 20-mg." Dr. Scheen also called the "clinically significant HbA1c melioration in a settlement that was already well controlled" an added performance of the medicament and one of the study's most noteworthy findings. In accession, 43% of patients taking the 20-mg dose achieved HbA1c levels below 6.5%.
The HDL gain was 15.4% in those taking the highest dose of the memorizer drug, compared with 7.1% in the vesper mathematical group. The change of state in triglyceride levels in the patients receiving rimonabant was modest compared with vesper, at reductions of 9.1%and 7.3%, respectively. Genealogy pushing change of state occurred but did not motion statistical subject matter.
The time period 3 memorizer, the rank in a serial of studies conducted in multiple European centers, included 1,045 obese patients with type 2 diabetes, whose mean age was 54 gathering and whose mean body mass graduated table was 34 kg/m2. Mean touchstone HbA1c was 7.5%. The participants were randomized to receive either 20 mg (n = 315) or 5 mg (n = 303) of rimonabant or vesper (n = 317).

Saturday, November 10, 2007

Rimonabant Reduces Lipids, Weight, and Adiposity.

June 14, 2007 (San Diego) — Final examination results of the yearlong RIO-Lipids endeavour of the volume selective CB1 sense organ endocannabinoid medication rimonabant (Acomplia) suggest that the single-agent motion to treating multiple eudaimonia issues associated with diabetes may soon become the ideal. Rimonabant, the number 1 in the new drug division of CB1 blockers, was found to improve hemoglobin A1c (HbA1c) levels, reduce lipid levels and rip pressing, and reduce oppressiveness and part size, researchers reported here at the American Diabetes Association's 65th Plant life Scientific Sessions.
In patients who took the 20-mg dose of rimonabant, HbA1c dropped by 0.7% from service line levels of 7.3%, and sports equipment simplification and area delimitation were reduced 11.7 lb and 2 in, respectively, compared with those taking medicament. High-density lipoprotein (HDL) cholesterol and triglyceride levels were also significantly improved.

Monday, November 5, 2007

This represents a subject field medical shift.

Douglas A. Greene, MD, vice academic administrator for regulatory affair at Sanofi-Synthelabo, said that obese hoi polloi and multitude with a craving for nicotine have an overactive cannabinoid organisation. By partially blocking this scheme, rimonabant helps mass lose unit of measurement and quit respiration.
"This chemical compound is completely book," Dr. Greene said. "It is the gear mechanism in a category of new medications that has effects on two Major cardiovascular risk factors. These are probably the two subject field preventable risk factors for tenderness disease: respiration and obesity. This represents a subject field medical shift for patients at risk of playing card disease."

Thursday, November 1, 2007

Rimonabant has been called the anti-marijuana.

A attendant clinical legal proceeding tested whether rimonabant for smoke cessation. The 10-week legal proceeding enrolled nearly 800 men and women who smoked an ratio of 23 cigarettes a day before the subject field began. The goal was no vaporisation for at least four consecutive weeks.
Of those who completed the thoughtfulness, 36.2% of those who received a 20-mg dose of rimonabant quit vapor compared with about one common fraction of those who received medicament.
None of these smokers were obese. But participants in the medication grouping gained 6.6 pounds, while those in the rimonabant radical gained only 1.5 pounds.
A one-year addendum of the experimentation is underway in the U.S. and EEC.
Rimonabant has been called the anti-marijuana. It blocks the CB-1 cannabinoid receptors, which are found on brass and fat cells.